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{ "code": 200, "msg": "ok！", "data": [ { "last_revised": null, "article_doi": "10.1371/journal.pone.0096938", "has_translated": 1, "article_id": "abs20181121215546044959486539", "published_time": "2014", "microsoft_id": null, "article_pmid": "24816837", "article_year": "2014", "article_language": "eng", "create_time": "2018-11-21T20:20:43.000Z", "upload_time": null, "received_time": "2013-12-18", "revise_time": null, "published_info": { "page": "e96938", "issue": "5", "volume": "9" }, "article_url": null, "file_size": 7.75, "full_text": null, "article_creator": "未知", "pubmed_revise": "2018-11-13", "article_pmcid": "PMC4016158", "has_abstract": 1, "article_name": "Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary", "published_time_precision": "Y", "accepted_time": "2014-04-13", "journal_info": { "journal_code": "J000221", "journal_name": "PLOS One" }, "is_del": 0, "original_file": "/static/file/original-article/2014/abs201811212155460449594865394691.pdf", "author_info": [ { "author_name": "Honoka Kiso", "author_id": "au20210424164628501527510790" }, { "author_name": "Katsu Takahashi", "author_id": "au20210423141411924897928783" }, { "author_name": "Kazuyuki Saito", "author_id": "au20210423120321866697220100" }, { "author_name": "Yumiko Togo", "author_id": "au20210424211414981974798403" }, { "author_name": "Hiroko Tsukamoto", "author_id": "au20210423205834318530500634" }, { "author_name": "Boyen Huang", "author_id": "au20210424152456121504898130" }, { "author_name": "Manabu Sugai", "author_id": "au20210424142812427130181642" }, { "author_name": "Akira Shimizu", "author_id": "au20210423115339328462921094" }, { "author_name": "Aris N. Economides", "author_id": "au20210423120529068340186848" }, { "author_name": "Harold C. Slavkin", "author_id": "au20210424141828364540221847" }, { "author_name": "Kazuhisa Bessho", "author_id": "au20210423202341831096658109" } ], "abstract_section": [ { "chs_text": "BMP-7和USAG-1（子宫致敏相关基因-1）之间的相互作用调节超数器官形成", "section_attr": 1, "eng_text": "Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations" }, { "chs_text": "骨形态发生蛋白（BMPs）是高度保守的信号分子，是转化生长因子（TGF）-β超家族的一部分，并且在许多器官的图案化和形态发生中起作用，包括牙列的发育。 BMP的功能由某些类别的分子控制，这些分子被识别为BMP拮抗剂，其抑制BMP与其同源受体的结合。在这项研究中，我们测试了USAG-1（子宫致敏相关基因-1）通过抑制BMP-7功能来抑制乳牙切牙的假设。我们了解到USAG-1和BMP-7在牙齿发育的晚期芽和早期帽期间在牙源性上皮和间充质中表达。 USAG-1是BMP拮抗剂，并且还调节Wnt信号传导。 USAG-1废除拯救了牙源性间充质细胞的凋亡消除。通过Msx1和Dlx2的表达以及Smad蛋白的磷酸化评估的基本上颌切牙中的BMP信号传导显着增强。使用外植体培养和随后的肾下囊移植E15 USAG-1突变体上颌切牙牙齿原基补充了BMP-7，在USAG-1 +/-以及USAG-1 - / - 救援和额外牙齿发育中证实。基于这些结果，我们得出结论，USAG-1在该模型系统中作为BMP-7的拮抗剂起作用。这些结果进一步表明，报道的USAG-1和BMP-7突变小鼠的表型为再生医学和牙科提供了机会。", "section_attr": 2, "eng_text": "Bone morphogenetic proteins (BMPs) are highly conserved signaling molecules that are part of the transforming growth factor (TGF)-beta superfamily, and function in the patterning and morphogenesis of many organs including development of the dentition. The functions of the BMPs are controlled by certain classes of molecules that are recognized as BMP antagonists that inhibit BMP binding to their cognate receptors. In this study we tested the hypothesis that USAG-1 (uterine sensitization-associated gene-1) suppresses deciduous incisors by inhibition of BMP-7 function. We learned that USAG-1 and BMP-7 were expressed within odontogenic epithelium as well as mesenchyme during the late bud and early cap stages of tooth development. USAG-1 is a BMP antagonist, and also modulates Wnt signaling. USAG-1 abrogation rescued apoptotic elimination of odontogenic mesenchymal cells. BMP signaling in the rudimentary maxillary incisor, assessed by expressions of Msx1 and Dlx2 and the phosphorylation of Smad protein, was significantly enhanced. Using explant culture and subsequent subrenal capsule transplantation of E15 USAG-1 mutant maxillary incisor tooth primordia supplemented with BMP-7 demonstrated in USAG-1+/- as well as USAG-1-/- rescue and supernumerary tooth development. Based upon these results, we conclude that USAG-1 functions as an antagonist of BMP-7 in this model system. These results further suggest that the phenotypes of USAG-1 and BMP-7 mutant mice reported provide opportunities for regenerative medicine and dentistry." } ], "type_info": [ { "type_name": "Research Support, Non-U.S. Gov't", "type_id": 62 }, { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": { "0": "USAG-1", "3": "Using", "5": "USAG-1+", "6": "USAG-1-" }, "highlight_chs_text": [ "USAG-1" ] }, { "last_revised": null, "article_doi": "10.1016/j.vaccine.2017.01.020", "has_translated": 1, "article_id": "abs20180824190243383676294339", "published_time": "2017-02-15", "microsoft_id": null, "article_pmid": "28117171", "article_year": "2017", "article_language": "eng", "create_time": "2018-08-24T11:03:02.000Z", "upload_time": null, "received_time": "2016-12-05", "revise_time": null, "published_info": { "page": "997-1000", "issue": "7", "volume": "35" }, "article_url": null, "file_size": 0.31, "full_text": null, "article_creator": "未知", "pubmed_revise": "2017-12-13", "article_pmcid": null, "has_abstract": 1, "article_name": "Impact of universal infant hepatitis B vaccination in the US-affiliated Pacific Islands, 1985-2015", "published_time_precision": "D", "accepted_time": "2017-01-12", "journal_info": { "journal_code": "J001253", "journal_name": "Vaccine" }, "is_del": 0, "original_file": "/static/file/original-article/2017/abs201808241902433836762943398944.pdf", "author_info": [ { "author_name": "W. E. Abara", "author_id": "au20210425023215439211727233" }, { "author_name": "M. G. Collier", "author_id": "au20210424164725635047725037" }, { "author_name": "E. H. Teshale", "author_id": "au20210424173642921190267968" } ], "abstract_section": [ { "chs_text": "1985 - 2015年美国附属太平洋岛屿普及婴儿乙型肝炎疫苗接种的影响", "section_attr": 1, "eng_text": "Impact of universal infant hepatitis B vaccination in the US-affiliated Pacific Islands, 1985-2015" }, { "chs_text": "美国附属的太平洋岛国（USAPI）是乙型肝炎病毒（HBV）感染的流行地区。 20世纪80年代中期，USAPI引入了普遍婴儿乙型肝炎疫苗接种，以减轻HBV负担。我们评估了普遍婴儿疫苗接种对USAPI中20世纪80年代，90年代和2000年代出生的儿童HBV感染率随时间的影响。获得了1985年至2015年间进行的系列血清学调查的人口统计学和血清学数据。进行描述性统计和方差分析。根据4827名儿童（2-11岁）的数据，HBV患病率显着下降：1980年代为8.4％; 20世纪90年代的2.5％;随着疫苗接种覆盖率的增加，2000年代增加了0.2％（P <0.0001）：20世纪80年代为76.4％; 20世纪90年代占87.3％;和2000年代的97.5％（P <0.0001）。这些发现强调了全球婴儿乙型肝炎疫苗接种随时间对HBV流行地区HBV负荷的保护作用。", "section_attr": 2, "eng_text": "The US-affiliated Pacific Island countries (USAPI) is an endemic region for hepatitis B virus (HBV) infection. Universal infant hepatitis B vaccination was introduced in the USAPI in the mid-1980s to mitigate the HBV burden. We assessed the impact of universal infant vaccination on the HBV infection prevalence over time among children born in the 1980s, 1990s, and 2000s in the USAPI. Demographic and serologic data from serial sero-surveys conducted between 1985 and 2015 were obtained. Descriptive statistics and analysis of variance were performed. From data obtained from 4827 children (2-11years), HBV prevalence decreased markedly: 8.4% in the 1980s; 2.5% in the 1990s; and 0.2% in the 2000s (P<0.0001) as vaccination coverage increased: 76.4% in the 1980s; 87.3% in the 1990s; and 97.5% in the 2000s (P<0.0001). These findings underscore the protective effect of universal infant hepatitis B vaccination over time on the HBV burden in an HBV endemic region." } ], "type_info": [ { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": { "0": "US-affiliated", "2": "USAPI" }, "highlight_chs_text": [ "USAPI" ] }, { "last_revised": null, "article_doi": "10.1097/MPG.0000000000000328", "has_translated": 1, "article_id": "abs20181126005248495273782747", "published_time": "2014-06", "microsoft_id": null, "article_pmid": "24509302", "article_year": "2014", "article_language": "eng", "create_time": "2018-11-25T16:55:48.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "756-61", "issue": "6", "volume": "58" }, "article_url": null, "file_size": 0.45, "full_text": null, "article_creator": "未知", "pubmed_revise": "2019-12-10", "article_pmcid": null, "has_abstract": 1, "article_name": "US-guided percutaneous liver biopsy in pediatric liver transplant recipients", "published_time_precision": "M", "accepted_time": null, "journal_info": { "journal_code": "J001524", "journal_name": "Journal of Pediatric Gastroenterology and Nutrition" }, "is_del": 0, "original_file": "/static/file/original-article/2014/abs201811260052484952737827472965.pdf", "author_info": [ { "author_name": "Soma Mandal", "author_id": "au20210423181208472245797925" } ], "abstract_section": [ { "chs_text": "美国指导的小儿肝移植受者经皮肝穿刺活检", "section_attr": 1, "eng_text": "US-guided percutaneous liver biopsy in pediatric liver transplant recipients" }, { "chs_text": "目标", "section_attr": 1, "eng_text": "OBJECTIVES" }, { "chs_text": "本研究评估了超声（US）引导的经皮肝脏活组织检查（PLBs）在小儿肝脏同种异体移植受者中的安全性，描述了移植后早期（≤12个月）和晚期（> 12个月）的病理结果，并分析了肝功能检查（LFTs）和多普勒US变量在确定这些结果时的价值。", "section_attr": 2, "eng_text": "The present study assesses the safety of ultrasound (US)-guided percutaneous liver biopsies (PLBs) within pediatric liver allograft recipients, describes the pathological results according to early (≤12 months) and late (>12 months) posttransplantation periods, and analyzes the value of liver function tests (LFTs) and Doppler US variables in determining these results." }, { "chs_text": "方法", "section_attr": 1, "eng_text": "METHODS" }, { "chs_text": null, "section_attr": 2, "eng_text": "A total of 219 US-guided PLBs in 85 pediatric patients with liver transplant (mean age 7 ± 5 years, range: 6 months to 18 years) performed between March 2005 and May 2012 were retrospectively evaluated at a single institution. Doppler US and LFT evaluation (including total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, alkaline phosphatase) occurred within 1 day of early (n = 92, 42%) and late term (n = 127, 58%) posttransplantation biopsies." }, { "chs_text": "结果", "section_attr": 1, "eng_text": "RESULTS" }, { "chs_text": null, "section_attr": 2, "eng_text": "The rate of major complications (hemorrhage requiring blood transfusion) was 0.91% (n = 2). The early versus late term biopsy results, respectively, included: cholestasis at 36% versus 18% (P = 0.003), minimal changes 16% versus 24% (not significant [NS]), acute rejection 13% versus 5% (P = 0.027), inflammatory diseases 15% versus 15% (NS), indeterminate acute rejection 11% versus 7% (NS), chronic rejection 4% versus 14% (P = 0.017), fibrotic diseases 4% versus 12% (NS), and other 0% versus 5% (NS). Neither LFT nor US variables were correlated with pathological outcomes." }, { "chs_text": "结论", "section_attr": 1, "eng_text": "CONCLUSIONS" }, { "chs_text": "美国引导的肝脏活检后儿科患者的并发症发生率很低。移植后早期和晚期肝脏活组织检查之间存在一系列病理结果。 LFT和多普勒美国研究结果不是病理结果的预测因子。", "section_attr": 2, "eng_text": "The rate of complications in pediatric patients after US-guided liver biopsy is low. A range of pathological results exists between early and late posttransplantation liver biopsies. LFT and Doppler US findings are not predictors of pathological results." } ], "type_info": [ { "type_name": "Evaluation Study", "type_id": 208 }, { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": { "0": "US-guided", "2": "US" }, "highlight_chs_text": [ "US" ] }, { "last_revised": null, "article_doi": "10.2105/AJPH.92.12.1958", "has_translated": 0, "article_id": "abs20190202175247439184677211", "published_time": "2002-12", "microsoft_id": null, "article_pmid": "12453816", "article_year": "2002", "article_language": "eng", "create_time": "2019-02-02T09:53:44.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "1958-63", "issue": "12", "volume": "92" }, "article_url": null, "file_size": 0.16, "full_text": null, "article_creator": "未知", "pubmed_revise": "2019-05-14", "article_pmcid": "PMC1447359", "has_abstract": 1, "article_name": "HIV prevalence among foreign- and US-born clients of public STD clinics", "published_time_precision": "M", "accepted_time": null, "journal_info": { "journal_code": "J000955", "journal_name": "American Journal of Public Health" }, "is_del": 0, "original_file": "/static/file/original-article/2002/abs201902021752474391846772118209.pdf", "author_info": [ { "author_name": "Nina T. Harawa", "author_id": "au20210423155511391781743805" } ], "abstract_section": [ { "chs_text": null, "section_attr": 1, "eng_text": "HIV prevalence among foreign- and US-born clients of public STD clinics" }, { "chs_text": null, "section_attr": 1, "eng_text": "OBJECTIVES" }, { "chs_text": null, "section_attr": 2, "eng_text": "We examined differences in HIV seroprevalence and the likely timing of HIV infection by birth region." }, { "chs_text": null, "section_attr": 1, "eng_text": "METHODS" }, { "chs_text": null, "section_attr": 2, "eng_text": "We analyzed unlinked HIV antibody data on 61 120 specimens from 7 public health centers in Los Angeles County from 1993 to 1999." }, { "chs_text": null, "section_attr": 1, "eng_text": "RESULTS" }, { "chs_text": null, "section_attr": 2, "eng_text": "Most (87%) immigrant clients were Central American/Mexican-born. HIV prevalence was similar for US- and foreign-born clients (1.8% [95% confidence interval (CI) = 1.7%, 1.9%] and 1.6% [95% CI = 1.5%, 1.8%], respectively). Seroprevalence was high among sub-Saharan African females and low among Asian/Pacific Islander males and females. For HIV-positive immigrants, the average age at and time since immigration were 20.6 years and 12.3 years, respectively." }, { "chs_text": null, "section_attr": 1, "eng_text": "CONCLUSIONS" }, { "chs_text": null, "section_attr": 2, "eng_text": "The relatively young age at arrival and long time since arrival for HIV-positive foreign-born clients suggest that most were infected after immigration." } ], "type_info": [ { "type_name": "Research Support, U.S. Gov't, P.H.S.", "type_id": 64 }, { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": [ "US-born", "US-" ] }, { "last_revised": null, "article_doi": "10.1093/infdis/jiw166", "has_translated": 1, "article_id": "abs20181021105626749234351367", "published_time": "2016-08-01", "microsoft_id": null, "article_pmid": "27122590", "article_year": "2016", "article_language": "eng", "create_time": "2018-10-21T03:01:30.000Z", "upload_time": null, "received_time": "2016-03-08", "revise_time": null, "published_info": { "page": "447-53", "issue": "3", "volume": "214" }, "article_url": null, "file_size": 0.44, "full_text": null, "article_creator": "未知", "pubmed_revise": "2020-03-06", "article_pmcid": "PMC4936647", "has_abstract": 1, "article_name": "Multiple Silent Introductions and Household Transmission of Methicillin-Resistant Staphylococcus aureus USA300", "published_time_precision": "D", "accepted_time": "2016-04-14", "journal_info": { "journal_code": "J000358", "journal_name": "The Journal of Infectious Diseases" }, "is_del": 0, "original_file": "/static/file/original-article/2016/abs201810211056267492343513675302.pdf", "author_info": [ { "author_name": "Michelle S. Toleman", "author_id": "au20210424192556770154973455" }, { "author_name": "Sandra Reuter", "author_id": "au20210423132729934794363533" }, { "author_name": "Francesc Coll", "author_id": "au20210423121448248973134575" }, { "author_name": "Ewan M. Harrison", "author_id": "au20210423125912766296107084" }, { "author_name": "Beth Blane", "author_id": "au20210423120626113670889096" }, { "author_name": "Nicholas M. Brown", "author_id": "au20210423120627376262388647" }, { "author_name": "M. Estee Torok", "author_id": "au20210423120853274469146862" }, { "author_name": "Julian Parkhill", "author_id": "au20210423120627609420301627" }, { "author_name": "Sharon J. Peacock", "author_id": "au20210423112724115337960512" } ], "abstract_section": [ { "chs_text": "系统监测检测英格兰东部耐甲氧西林金黄色葡萄球菌USA300的多次静默引入和家庭传播", "section_attr": 1, "eng_text": "Systematic Surveillance Detects Multiple Silent Introductions and Household Transmission of Methicillin-Resistant Staphylococcus aureus USA300 in the East of England" }, { "chs_text": "背景", "section_attr": 1, "eng_text": "BACKGROUND" }, { "chs_text": "美国300耐甲氧西林金黄色葡萄球菌（MRSA）在美国的传播导致感染流行。在欧洲，仅描述了散发病例或USA300感染的小群，并且其在英国的流行情况未知。我们在英格兰东部对USA300进行了前瞻性监测。", "section_attr": 2, "eng_text": "The spread of USA300 methicillin-resistant Staphylococcus aureus (MRSA) across the United States resulted in an epidemic of infections. In Europe, only sporadic cases or small clusters of USA300 infections are described, and its prevalence in England is unknown. We conducted prospective surveillance for USA300 in the east of England." }, { "chs_text": "方法", "section_attr": 1, "eng_text": "METHODS" }, { "chs_text": "我们对提交给微生物实验室的社区和医院样本中分离出的所有MRSA患者进行了为期12个月的前瞻性观察性队列研究。来自每个个体的至少1个MRSA分离物经历全基因组测序。在序列分析的基础上鉴定了USA300，并且在这些和来自美国的USA300基因组之间进行了系统发育比较。", "section_attr": 2, "eng_text": "We undertook a 12-month prospective observational cohort study of all individuals with MRSA isolated from community and hospital samples submitted to a microbiology laboratory. At least 1 MRSA isolate from each individual underwent whole-genome sequencing. USA300 was identified on the basis of sequence analysis, and phylogenetic comparisons were made between these and USA300 genomes from the United States." }, { "chs_text": "结果", "section_attr": 1, "eng_text": "RESULTS" }, { "chs_text": "在2012年4月至2013年4月期间，我们对来自1465个个体的2283个MRSA分离株（在运输筛选和临床样品中检测到）进行了测序。从24例（1.6％）中分离出USA300。 10例（42％）有皮肤和软组织感染，2例有侵袭性疾病。系统发育分析确定了USA300的多次引入和家庭传播。", "section_attr": 2, "eng_text": "Between April 2012 and April 2013, we sequenced 2283 MRSA isolates (detected during carriage screening and in clinical samples) from 1465 individuals. USA300 was isolated from 24 cases (1.6%). Ten cases (42%) had skin and soft tissue infection, and 2 cases had invasive disease. Phylogenetic analyses identified multiple introductions and household transmission of USA300." }, { "chs_text": "结论", "section_attr": 1, "eng_text": "CONCLUSIONS" }, { "chs_text": "使用诊断实验室作为监测的哨兵已确定2012 - 2013年在英格兰东部重复引入USA300，证据表明传播有限。我们的研究结果表明系统监测如何能够提供菌株出现和传播的早期预警。", "section_attr": 2, "eng_text": "Use of a diagnostic laboratory as a sentinel for surveillance has identified repeated introductions of USA300 in eastern England in 2012-2013, with evidence for limited transmission. Our results show how systematic surveillance could provide an early warning of strain emergence and dissemination." } ], "type_info": [ { "type_name": "Journal Article", "type_id": 39 }, { "type_name": "Observational Study", "type_id": 48 } ], "highlight_eng_text": { "0": "USA300", "3": "USA300.", "4": "Use" }, "highlight_chs_text": [ "USA300" ] }, { "last_revised": null, "article_doi": "10.1128/IAI.00704-15", "has_translated": 1, "article_id": "abs20181020224610765376325083", "published_time": "2016-01", "microsoft_id": null, "article_pmid": "26502911", "article_year": "2016", "article_language": "eng", "create_time": "2018-10-20T14:46:29.000Z", "upload_time": null, "received_time": "2015-05-31", "revise_time": null, "published_info": { "page": "241-53", "issue": "1", "volume": "84" }, "article_url": null, "file_size": 2.57, "full_text": null, "article_creator": "未知", "pubmed_revise": "2018-11-13", "article_pmcid": "PMC4694005", "has_abstract": 1, "article_name": "Staphylococcus aureus Strain USA300 Perturbs Acquisition of Lysosomal Enzymes and Requires Phagosomal", "published_time_precision": "M", "accepted_time": "2015-10-22", "journal_info": { "journal_code": "J003957", "journal_name": "Infection and Immunity" }, "is_del": 0, "original_file": "/static/file/original-article/2016/abs201810202246107653763250838482.pdf", "author_info": [ { "author_name": "Zachary R. Tranchemontagne", "author_id": "au20210425003445177307366738" }, { "author_name": "Ryan B. Camire", "author_id": "au20210424221331804738488237" }, { "author_name": "Vanessa J. O'Donnell", "author_id": "au20210425003445243121227423" }, { "author_name": "Jessfor Baugh", "author_id": "au20210425003445278154514742" }, { "author_name": "Kristin M. Burkholder", "author_id": "au20210424150302105098601722" } ], "abstract_section": [ { "chs_text": "金黄色葡萄球菌菌株USA300 Perturbs获取溶酶体酶并需要吞噬体酸化以在巨噬细胞内存活", "section_attr": 1, "eng_text": "Staphylococcus aureus Strain USA300 Perturbs Acquisition of Lysosomal Enzymes and Requires Phagosomal Acidification for Survival inside Macrophages" }, { "chs_text": "耐甲氧西林金黄色葡萄球菌（MRSA）引起侵入性，耐药性皮肤和软组织感染。有关金黄色葡萄球菌在巨噬细胞内存活的报道表明，巨噬细胞内的环境可能是持续感染的一个利基;然而，细菌可能逃避巨噬细胞吞噬体防御的机制尚不清楚。我们通过评估细菌细胞内存活和吞噬体酸化和成熟以及通过测试吞噬体条件对细菌活力的影响来检查含有金黄色葡萄球菌的吞噬体在THP-1巨噬细胞中的命运。多种金黄色葡萄球菌菌株在巨噬细胞内存活，并且在使用MRSA USA300克隆的研究中，含有USA300的吞噬体快速酸化并获得晚期内体和溶酶体蛋白LAMP1。然而，与含有与溶酶体水解酶组织蛋白酶D和β-葡糖醛酸糖苷酶相关的死细菌的吞噬体相比，含有活USA300细菌的吞噬体较少。抑制溶酶体水解酶活性对USA300或其他金黄色葡萄球菌菌株的细胞内存活没有影响，表明金黄色葡萄球菌扰乱了溶酶体酶的获得。我们检测了酸化对金黄色葡萄球菌巨噬细胞存活率的影响，发现吞噬体酸化抑制剂显着损害USA300细胞内存活。抑制巨噬细胞吞噬体酸化导致葡萄球菌毒力调节剂agr的USA300表达减少30倍，但对sarA，saeR或sigB的表达几乎没有影响。体外酸性pH的细菌暴露增加了agr表达。总之，这些结果表明金黄色葡萄球菌通过扰乱正常的吞噬溶酶体形成而在巨噬细胞内存活，并且USA300可以感知吞噬体条件并且上调关键毒力调节剂的表达，其使得其细胞内存活。", "section_attr": 2, "eng_text": "Methicillin-resistant Staphylococcus aureus (MRSA) causes invasive, drug-resistant skin and soft tissue infections. Reports that S. aureus bacteria survive inside macrophages suggest that the intramacrophage environment may be a niche for persistent infection; however, mechanisms by which the bacteria might evade macrophage phagosomal defenses are unclear. We examined the fate of the S. aureus-containing phagosome in THP-1 macrophages by evaluating bacterial intracellular survival and phagosomal acidification and maturation and by testing the impact of phagosomal conditions on bacterial viability. Multiple strains of S. aureus survived inside macrophages, and in studies using the MRSA USA300 clone, the USA300-containing phagosome acidified rapidly and acquired the late endosome and lysosome protein LAMP1. However, fewer phagosomes containing live USA300 bacteria than those containing dead bacteria associated with the lysosomal hydrolases cathepsin D and β-glucuronidase. Inhibiting lysosomal hydrolase activity had no impact on intracellular survival of USA300 or other S. aureus strains, suggesting that S. aureus perturbs acquisition of lysosomal enzymes. We examined the impact of acidification on S. aureus intramacrophage viability and found that inhibitors of phagosomal acidification significantly impaired USA300 intracellular survival. Inhibition of macrophage phagosomal acidification resulted in a 30-fold reduction in USA300 expression of the staphylococcal virulence regulator agr but had little effect on expression of sarA, saeR, or sigB. Bacterial exposure to acidic pH in vitro increased agr expression. Together, these results suggest that S. aureus survives inside macrophages by perturbing normal phagolysosome formation and that USA300 may sense phagosomal conditions and upregulate expression of a key virulence regulator that enables its intracellular survival." } ], "type_info": [ { "type_name": "Research Support, Non-U.S. Gov't", "type_id": 62 }, { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": { "0": "USA300", "1": "using", "3": "USA300-containing" }, "highlight_chs_text": [ "USA300" ] }, { "last_revised": null, "article_doi": "10.1007/s11250-011-9929-7", "has_translated": 1, "article_id": "abs20190713143928817487924687", "published_time": "2012-03", "microsoft_id": null, "article_pmid": "21786161", "article_year": "2012", "article_language": "eng", "create_time": "2019-07-13T06:40:31.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "379-82", "issue": "3", "volume": "44" }, "article_url": null, "file_size": 0.1, "full_text": null, "article_creator": "未知", "pubmed_revise": "2019-12-10", "article_pmcid": null, "has_abstract": 1, "article_name": "Estimation of the diagnostic accuracy of the glyco-C and US9 gene-based polymerase chain reaction technique", "published_time_precision": "M", "accepted_time": "2011-07-14", "journal_info": { "journal_code": "J005119", "journal_name": "Tropical Animal Health and Production" }, "is_del": 0, "original_file": "/static/file/original-article/2012/abs201907131439288174879246875672.pdf", "author_info": [ { "author_name": "Tereza Cristina Cardoso", "author_id": "au20210423133044373208790477" }, { "author_name": "Talita Fontes Antello", "author_id": "au20210424163527378697951771" }, { "author_name": "Flávia Volpato Vieira", "author_id": "au20210424163527389707575813" }, { "author_name": "Saulo Tarso Zacarias Machado", "author_id": "au20210424163527397715996657" }, { "author_name": "Adriana Hellmeister de Campos Nogueira", "author_id": "au20210424163527403720535729" } ], "abstract_section": [ { "chs_text": "估计基于糖-C和US9基因的聚合酶链反应技术在巴西屠宰场的腐烂脑悬液中检测牛疱疹病毒5型DNA的诊断准确性", "section_attr": 1, "eng_text": "Estimation of the diagnostic accuracy of the glyco-C and US9 gene-based polymerase chain reaction technique for the detection of bovine Herpesvirus type 5 DNA in decomposed brain suspension from a slaughter house using Bayesian analysis, Brazil" }, { "chs_text": null, "section_attr": 2, "eng_text": "Brazil represents the greatest beef producer among tropical countries, and the major obstacle for meat international trade is sanitary problems especially closely related to viral encephalitis. The goal of this study was to estimate the accuracy of the glycol and US9 gene-based polymerase chain reactions (PCRs) for the detection of bovine Herpesvirus type 5 (BoHV-5) from decomposed brain samples (n = 95). For this purpose, a latent-class (bayesian) approach was used. Sensitivity (Se) was estimated to be 70% (95% probability interval, 40-80) and specificity (Sp) 100% in the statistical analysis for both PCRs used. Accordingly, a minimum of ≥40% of the calves was estimated to harbor BoHV-5 DNA even after 72 h of decomposition at room temperature. It was concluded that US9 gene-based PCR could also be considered a cost-effective alternative in sanitary programmers. However, given the importance of veterinary diagnoses, PCR-positive samples should be further confirmed through in vitro isolation and/or sequencing." } ], "type_info": [ { "type_name": "Research Support, Non-U.S. Gov't", "type_id": 62 }, { "type_name": "Evaluation Study", "type_id": 208 }, { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": { "0": "US9", "2": "used.", "3": "used" }, "highlight_chs_text": [ "US9" ] }, { "last_revised": null, "article_doi": "10.1128/JCM.44.1.225-226.2006", "has_translated": 1, "article_id": "abs20181212232107136297128954", "published_time": "2006-01", "microsoft_id": null, "article_pmid": "16390975", "article_year": "2006", "article_language": "eng", "create_time": "2018-12-12T15:21:54.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "225-6", "issue": "1", "volume": "44" }, "article_url": null, "file_size": 0.06, "full_text": null, "article_creator": "未知", "pubmed_revise": "2018-11-13", "article_pmcid": "PMC1351968", "has_abstract": 1, "article_name": "Community-associated methicillin-resistant Staphylococcus aureus epidemic clone USA300 in isolates from", "published_time_precision": "M", "accepted_time": null, "journal_info": { "journal_code": "J000166", "journal_name": "Journal of Clinical Microbiology" }, "is_del": 0, "original_file": "/static/file/original-article/2006/abs201812122321071362971289546295.pdf", "author_info": [ { "author_name": "Jill C. Roberts", "author_id": "au20210424145625054091186197" }, { "author_name": "Robin L. Krueger", "author_id": "au20210424151308802865795834" } ], "abstract_section": [ { "chs_text": "佛罗里达州和华盛顿州分离株中与社区相关的耐甲氧西林金黄色葡萄球菌流行病克隆USA300", "section_attr": 1, "eng_text": "Community-associated methicillin-resistant Staphylococcus aureus epidemic clone USA300 in isolates from Florida and Washington" }, { "chs_text": "我们检查了来自佛罗里达州和华盛顿州的299株甲氧西林耐药，社区相关的金黄色葡萄球菌分离株中是否存在USA300流行病克隆。脉冲场凝胶电泳显示了43％的金黄色葡萄球菌菌株和两种状态的分离株中的流行病克隆。大多数USA300分离株（88％）来自伤口感染。", "section_attr": 2, "eng_text": "We examined 299 methicillin-resistant, community-associated Staphylococcus aureus isolates from Florida and Washington State for the presence of the USA300 epidemic clone. Pulsed-field gel electrophoresis demonstrated the epidemic clone in 43% of our S. aureus strains and in isolates from both states. The majority of the USA300 isolates (88%) were from wound infections." } ], "type_info": [ { "type_name": "Research Support, U.S. Gov't, Non-P.H.S.", "type_id": 63 }, { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": [ "USA300" ], "highlight_chs_text": [ "USA300" ] }, { "last_revised": null, "article_doi": "10.1093/jurban/78.4.627", "has_translated": 0, "article_id": "abs20190219133602304589749388", "published_time": "2001-12", "microsoft_id": null, "article_pmid": "11796809", "article_year": "2001", "article_language": "eng", "create_time": "2019-02-19T05:36:50.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "627-37", "issue": "4", "volume": "78" }, "article_url": null, "file_size": 0.08, "full_text": null, "article_creator": "未知", "pubmed_revise": "2018-11-30", "article_pmcid": "PMC3455870", "has_abstract": 1, "article_name": "Reproductive health differences among Latin American- and US-born young women", "published_time_precision": "M", "accepted_time": null, "journal_info": { "journal_code": "J002325", "journal_name": "Journal of Urban Health" }, "is_del": 0, "original_file": "/static/file/original-article/2001/abs201902191336023045897493883587.pdf", "author_info": [ { "author_name": "A. M. Minnis", "author_id": "au20210424140454468982258926" } ], "abstract_section": [ { "chs_text": null, "section_attr": 1, "eng_text": "Reproductive health differences among Latin American- and US-born young women" }, { "chs_text": null, "section_attr": 2, "eng_text": "Investigations of reproductive health within Latinos living in the United States suggest that sexual behaviors and contraception use practices vary by ethnicity and between foreign- and US-born adolescents. This article compares high-risk sexual behaviors and reproductive health among foreign-born Latinas, US-born Latinas, and US-born non-Latinas aged 15-24 years. We recruited 361 females from reproductive health clinics in the San Francisco Bay Area of California between 1995 and 1998; these women completed an interview that assessed sexual risk behaviors and history of pregnancy, abortion, and sexually transmitted infections. Current chlamydial and gonococcal infections were detected through biological testing. Among participants aged 15-18 years, US-born Latinas were more likely to have been pregnant (odds ratio [OR] comparing US-born Latinas and US-born non-Latinas = 3.9, 95% confidence interval [CI] 1.3, 11.4), whereas among respondents aged 19-24 years, foreign-born Latinas were more likely to have been pregnant than US-born Latinas (OR = 11.3, 95% CI 1.0, 130.8) and US-born non-Latinas (OR = 64.2, 95% CI 9.9, 416.3). US-born Latinas were most likely to have had an abortion (OR comparing US-born Latinas and US-born non-Latinas = 2.0, 95% CI 0.9, 4.7). They were also most likely to have chlamydial infection at study enrollment (8.2% prevalence compared to 2.2% and 1.0%for foreign-born Latinas and US-born non-Latinas, respectively; P =.009). Reproductive health differences between foreign and US-born females and within the US-born population warrant further examination and highlight the need for targeted prevention." } ], "type_info": [ { "type_name": "Journal Article", "type_id": 39 }, { "type_name": "Comparative Study", "type_id": 18 } ], "highlight_eng_text": [ "use", "US-born" ] }, { "last_revised": null, "article_doi": "10.1007/s10552-017-0973-0", "has_translated": 1, "article_id": "abs20180826063019315547333847", "published_time": "2017-11", "microsoft_id": null, "article_pmid": "29098504", "article_year": "2017", "article_language": "eng", "create_time": "2018-08-25T22:31:25.000Z", "upload_time": null, "received_time": "2016-09-06", "revise_time": null, "published_info": { "page": "1341-1347", "issue": "11", "volume": "28" }, "article_url": null, "file_size": 0.64, "full_text": null, "article_creator": "未知", "pubmed_revise": "2019-08-27", "article_pmcid": "PMC6707718", "has_abstract": 1, "article_name": "Examining HPV- and HPV vaccine-related cognitions and acceptability among US-born and immigrant hispanics", "published_time_precision": "M", "accepted_time": "2017-10-24", "journal_info": { "journal_code": "J001773", "journal_name": "Cancer Causes & Control" }, "is_del": 0, "original_file": "/static/file/original-article/2017/abs201808260630193155473338472014.pdf", "author_info": [ { "author_name": "Kimlin Tam Ashing", "author_id": "au20210423121931382282731182" }, { "author_name": "Agatha Carrington", "author_id": "au20210424153605813070802112" }, { "author_name": "Veronica Roach", "author_id": "au20210424162135607307166777" } ], "abstract_section": [ { "chs_text": "研究美国出生的和移民的西班牙裔和美国出生的和移民的非西班牙裔黑人与hpv和hpv疫苗相关的认知和可接受性：一项初步的集水区研究", "section_attr": 1, "eng_text": "Examining HPV- and HPV vaccine-related cognitions and acceptability among US-born and immigrant hispanics and US-born and immigrant non-Hispanic Blacks: a preliminary catchment area study" }, { "chs_text": "目的", "section_attr": 1, "eng_text": "PURPOSE" }, { "chs_text": "存在HPV疫苗接种的差异。因此，我们调查了美国出生的非裔美国人（AA）和黑人移民以及美国出生的拉丁裔和拉丁裔移民之间HPV和HPV疫苗相关认知和可接受性的区别和差异。", "section_attr": 2, "eng_text": "Disparities in HPV vaccination exist. Therefore, we investigated the distinction and disparities in HPV- and HPV vaccine-related cognitions and acceptability among US-born African Americans (AA) and Black immigrants, and between US-born Latinas and Latina immigrants." }, { "chs_text": "方法", "section_attr": 1, "eng_text": "METHODS" }, { "chs_text": null, "section_attr": 2, "eng_text": "Secondary data analyses were conducted with 383 female adults divided into non-Hispanic Blacks-(1) AA born in the US (n = 129) and (2) Black immigrants (n = 53), and Hispanics-(3) Latinas born in the US (n = 57) and (4) Latina immigrants (n = 144). HPV-related cognitions are assessed by measuring HPV-related knowledge and HPV vaccine-related awareness, beliefs, accessibility, and acceptability." }, { "chs_text": "结果", "section_attr": 1, "eng_text": "RESULTS" }, { "chs_text": null, "section_attr": 2, "eng_text": "Black and Latina immigrants were less likely to know where they can get/refer for HPV vaccine (p = .007) than their US-born counterparts. Latina immigrants were less likely to have heard of HPV vaccine (p = .033), know where they can get more information about HPV vaccine (p = .045), and know where they can get/refer for HPV vaccine (p = .001) than US-born Latinas. Both immigrant groups (Black: p = .046; Latina: p = .044) were more likely to report cost concerns than their counterparts. US-born AA were the least likely to endorse HPV vaccine safety (31.0%) and efficacy (39.7%), whereas US-born Latinas endorsed efficacy (63.2%) but less safety (44.6%). Overall, vaccine acceptability was low across all groups." }, { "chs_text": "结论", "section_attr": 1, "eng_text": "CONCLUSIONS" }, { "chs_text": "出现了HPV疫苗认知的群体差异，但它们都具有显着的HPV疫苗可接受性（安全性和有效性）障碍。 HPV疫苗的安全性和有效性在美国出生的AA中非常不利。 HPV疫苗的安全性问题得到证实，只有31-54％的人报告称“HPV疫苗是安全的” - 可能会增加HPV疫苗否定的风险。关于HPV疫苗功效，该研究人群中只有40-63％支持HPV疫苗功效。此外，移民报告了更高的HPV疫苗成本障碍和医疗保健准入问题 - 增加了HPV疫苗天真的风险。因此，我们对HPV疫苗认知和可接受性的研究结果可以为有针对性的策略提供信息，以增加美国和移民西班牙裔和非西班牙裔黑人的疫苗接种率，这些黑人患HPV相关癌症的风险较高。", "section_attr": 2, "eng_text": "Group disparities in HPV vaccine cognitions emerged, but they all had notable HPV vaccine acceptability (safety and efficacy) barriers. HPV vaccine safety and efficacy were highly unfavorable in US-born AA. The HPV vaccine safety concerns are demonstrated with only 31-54% reporting that the \"HPV vaccine is safe\"-potentially increasing their risk of HPV vaccine negation. With regards to HPV vaccine efficacy, only 40-63% of this study population endorsed HPV vaccine efficacy. Additionally, immigrants reported greater HPV vaccine cost barriers and healthcare access concerns-increasing their risk for HPV vaccine naiveté. Therefore, our findings on HPV vaccine cognitions and acceptability can inform targeted strategies to increase vaccination among US and immigrant Hispanics and non-Hispanic Blacks who are at elevated risk for HPV-related cancers." } ], "type_info": [ { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": [ "US-born" ] }, { "last_revised": null, "article_doi": "10.1177/1076029609339748", "has_translated": 0, "article_id": "abs20190219221419995474912091", "published_time": "2009-12", "microsoft_id": null, "article_pmid": "19850586", "article_year": "2009", "article_language": "eng", "create_time": "2019-02-19T14:15:15.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "645-51", "issue": "6", "volume": "15" }, "article_url": null, "file_size": 0.11, "full_text": null, "article_creator": "未知", "pubmed_revise": "2009-11-20", "article_pmcid": null, "has_abstract": 1, "article_name": "European community and US-FDA approval of recombinant human antithrombin produced in genetically altered", "published_time_precision": "M", "accepted_time": null, "journal_info": { "journal_code": "J002189", "journal_name": "Clinical and Applied Thrombosis/Hemostasis" }, "is_del": 0, "original_file": "/static/file/original-article/2009/abs201902192214199954749120919886.pdf", "abstract_section": [ { "chs_text": null, "section_attr": 1, "eng_text": "European community and US-FDA approval of recombinant human antithrombin produced in genetically altered goats" }, { "chs_text": null, "section_attr": 2, "eng_text": "Thrombin and factor Xa play a central role in thrombogenesis in both medical and surgical patients. Antithrombin (AT) is the key inhibitor, which controls the action of these enzymes in hypercoagulable states. The AT concentrates prepared from human blood have been used to treat patients with thrombotic disorders and heparin resistance. The AT concentrates are prepared from pooled human plasma and beside limited supply, suffer from viral and other biological contaminants. The availability of recombinant human AT (rhAT) obtained from genetically engineered goats provide a biologically equivalent product that can be used in practically all indications where human AT is indicated including heparin resistance. Moreover, because of its high affinity to heparin and related drugs, recombinant AT can also be developed in further indications. On review of the preclinical and clinical data on the safety and efficacy, the European Union and U.S. Food and Drug Administration (US-FDA) have recently approved the use of rhAT in specified clinical indications." } ], "type_info": [ { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": { "0": "US-FDA", "1": "used", "4": "use" } }, { "last_revised": null, "article_doi": "10.1177/0141076814530684", "has_translated": 1, "article_id": "abs20181130173442810655727719", "published_time": "2014-05", "microsoft_id": null, "article_pmid": "24833655", "article_year": "2014", "article_language": "eng", "create_time": "2018-11-30T09:35:25.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "187-193", "issue": "5", "volume": "107" }, "article_url": null, "file_size": 0.39, "full_text": null, "article_creator": "未知", "pubmed_revise": "2020-06-11", "article_pmcid": "PMC4023518", "has_abstract": 1, "article_name": "Living conditions in Iraq: 10 years after the US-led invasion", "published_time_precision": "M", "accepted_time": null, "journal_info": { "journal_code": "J002101", "journal_name": "Journal of the Royal Society of Medicine" }, "is_del": 0, "original_file": "/static/file/original-article/2014/abs201811301734428106557277194226.pdf", "author_info": [ { "author_name": "S. Rawaf", "author_id": "au20210424123945892760522572" }, { "author_name": "S. Hassounah", "author_id": "au20210424214607953614740079" }, { "author_name": "E. Dubois", "author_id": "au20210423122712383781676668" }, { "author_name": "B. Abdalrahman", "author_id": "au20210424210446409144735462" }, { "author_name": "M. Raheem", "author_id": "au20210424143711741199262967" }, { "author_name": "H. Jamil", "author_id": "au20210423171329969569797164" }, { "author_name": "A. Majeed", "author_id": "au20210423115021675196337795" } ], "abstract_section": [ { "chs_text": "伊拉克的生活条件：美国领导的入侵10年后", "section_attr": 1, "eng_text": "Living conditions in Iraq: 10 years after the US-led invasion" }, { "chs_text": "在20世纪80年代早期，伊拉克是一个中等收入和快速发展的国家，拥有完善的卫生系统。几十年后 - 战争结束后，制裁和暴力教派激增 - 儿童和孕产妇健康指标恶化，其贫困人口指数为22.9％，霍乱等疾病重新出现。今天，伊拉克受到长期政治僵局和经济挑战复杂的困扰;因此，生活的各个方面都在受苦，包括健康。无论通过国家和国际努力改善卫生系统组成部分的巨大投资，人口的健康状况只能通过影响健康的生活的其他方面的响亮和协同努力来推进：健康的社会决定因素。", "section_attr": 2, "eng_text": "In the early 1980s, Iraq was a middle-income and rapidly developing country with a well-developed health system. A few decades later - after wars, sanctions and a violent sectarian upsurge - child and maternal health indicators have deteriorated, its poverty headcount index is at 22.9% and diseases such as cholera have remerged. Today Iraq is beset by chronic political deadlock and a complexity of economic challenges; accordingly, all aspects of life are suffering, including health. Irrespective of the monumental investment to improve components of the health system, via national and international efforts, the health status of the population can only advance through resounding and synergistic effort in other aspects of life affecting health: the social determinants of health." } ], "type_info": [ { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": [ "US-led" ] }, { "last_revised": null, "article_doi": "10.1016/j.cell.2018.10.029", "has_translated": 0, "article_id": "abs20181213052154004861686668", "published_time": "2018-11-01", "microsoft_id": null, "article_pmid": "30388453", "article_year": "2018", "article_language": "eng", "create_time": "2018-12-12T21:22:44.000Z", "upload_time": null, "received_time": "2018-08-22", "revise_time": null, "published_info": { "page": "962-972.e10", "issue": "4", "volume": "175" }, "article_url": null, "file_size": 8.23, "full_text": null, "article_creator": "未知", "pubmed_revise": "2020-03-09", "article_pmcid": "PMC6498444", "has_abstract": 1, "article_name": "US Immigration Westernizes the Human Gut Microbiome", "published_time_precision": "D", "accepted_time": "2018-10-12", "journal_info": { "journal_code": "J000026", "journal_name": "Cell" }, "is_del": 0, "original_file": "/static/file/original-article/2018/abs201812130521540048616866689535.pdf", "author_info": [ { "author_name": "Pajau Vangay", "author_id": "au20210424170047355708585442" }, { "author_name": "Abigail J. Johnson", "author_id": "au20210424170047314821210471" }, { "author_name": "Tonya L. Ward", "author_id": "au20210424162033643038763110" }, { "author_name": "Gabriel A. Al-Ghalith", "author_id": "au20210424170047370722849894" }, { "author_name": "Robin R. Shields-Cutler", "author_id": "au20210424170047400750540223" }, { "author_name": "Sarah K. Lucas", "author_id": "au20210424204834453372396587" }, { "author_name": "Lalit K. Beura", "author_id": "au20210424161141591432571085" }, { "author_name": "Emily A. Thompson", "author_id": "au20210424165719331455772017" }, { "author_name": "Lisa M. Till", "author_id": "au20210424165807597070933275" }, { "author_name": "Rodolfo Batres", "author_id": "au20210425080859244964913223" }, { "author_name": "Bwei Paw", "author_id": "au20210425080859259979957322" }, { "author_name": "Shannon L. Pergament", "author_id": "au20210424161207920824109437" }, { "author_name": "Pimpanitta Saenyakul", "author_id": "au20210425023248054980916374" }, { "author_name": "Mary Xiong", "author_id": "au20210425080859299996700241" }, { "author_name": "Grant Kim", "author_id": "au20210425080859336029145626" }, { "author_name": "David Masopust", "author_id": "au20210423122431102418806510" }, { "author_name": "Eric C. Martens", "author_id": "au20210423130037104918422970" }, { "author_name": "Rose McGready", "author_id": "au20210423122832112950365020" }, { "author_name": "Purna C. Kashyap", "author_id": "au20210423190859996284618567" }, { "author_name": "Kathleen A. Culhane-Pera", "author_id": "au20210424141653799597550291" }, { "author_name": "Dan Knights", "author_id": "au20210423142255689795610743" } ], "abstract_section": [ { "chs_text": null, "section_attr": 1, "eng_text": "US Immigration Westernizes the Human Gut Microbiome" }, { "chs_text": null, "section_attr": 2, "eng_text": "Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations." } ], "type_info": [ { "type_name": "Research Support, Non-U.S. Gov't", "type_id": 62 }, { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": { "0": "US", "2": "US-born", "3": "Using", "4": "US-associated" } }, { "last_revised": null, "article_doi": "10.2105/AJPH.2006.106443", "has_translated": 0, "article_id": "abs20190202065413610806333295", "published_time": "2008-11", "microsoft_id": null, "article_pmid": "18309140", "article_year": "2008", "article_language": "eng", "create_time": "2019-02-01T22:55:06.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "2042-50", "issue": "11", "volume": "98" }, "article_url": null, "file_size": 0.5, "full_text": null, "article_creator": "未知", "pubmed_revise": "2018-12-01", "article_pmcid": "PMC2636422", "has_abstract": 1, "article_name": "and sexually transmitted infection risk behaviors and beliefs among Black West Indian immigrants and US-born", "published_time_precision": "M", "accepted_time": null, "journal_info": { "journal_code": "J000955", "journal_name": "American Journal of Public Health" }, "is_del": 0, "original_file": "/static/file/original-article/2008/abs201902020654136108063332958532.pdf", "author_info": [ { "author_name": "Susie Hoffman", "author_id": "au20210423193817343427468163" }, { "author_name": "Sharlene T. Beckford Jarrett", "author_id": "au20210424154634294579657364" } ], "abstract_section": [ { "chs_text": null, "section_attr": 1, "eng_text": "HIV and sexually transmitted infection risk behaviors and beliefs among Black West Indian immigrants and US-born Blacks" }, { "chs_text": null, "section_attr": 1, "eng_text": "OBJECTIVES" }, { "chs_text": null, "section_attr": 2, "eng_text": "We compared Black West Indian immigrants' and US-born Blacks' sexual and drug-use risk behaviors and their beliefs related to using condoms and informing partners of sexually transmitted infections (STIs) to identify possible differences in risk." }, { "chs_text": null, "section_attr": 1, "eng_text": "METHODS" }, { "chs_text": null, "section_attr": 2, "eng_text": "We drew data from the baseline assessment of a clinic-based intervention designed to increase partner STI notification." }, { "chs_text": null, "section_attr": 1, "eng_text": "RESULTS" }, { "chs_text": null, "section_attr": 2, "eng_text": "Black West Indian men were less likely than were US-born Black men to report nonregular partners. There were no differences in condom use. US-born Black women were more likely than were Black West Indian women to be extremely confident that they could convince their regular partners to use condoms (odds ratio [OR] = 2.40; 95% confidence interval [CI] = 1.21, 4.76), whereas there were no differences between Black West Indian and US-born Black men on this measure (interaction P = .06). US-born Black women were more likely than were Black West Indian women to be extremely confident in their ability to discuss STI screening with their regular partners (OR = 1.89; 95% CI = 1.03, 3.47)." }, { "chs_text": null, "section_attr": 1, "eng_text": "CONCLUSIONS" }, { "chs_text": null, "section_attr": 2, "eng_text": "Black West Indian women's lower levels of confidence that they can discuss STI screening with their regular partners and convince these partners to use condoms may increase their infection risk. Gender-sensitive interventions are warranted for Black West Indian immigrants, especially women." } ], "type_info": [ { "type_name": "Comparative Study", "type_id": 18 }, { "type_name": "Randomized Controlled Trial", "type_id": 58 }, { "type_name": "Journal Article", "type_id": 39 }, { "type_name": "Research Support, U.S. Gov't, P.H.S.", "type_id": 64 }, { "type_name": "Research Support, U.S. Gov't, Non-P.H.S.", "type_id": 63 } ], "highlight_eng_text": { "0": "US-born", "2": "use", "4": "use." } }, { "last_revised": null, "article_doi": "10.1093/cid/cix327", "has_translated": 1, "article_id": "abs20180825012227210367583085", "published_time": "2017-08-01", "microsoft_id": null, "article_pmid": "28419202", "article_year": "2017", "article_language": "eng", "create_time": "2018-08-24T17:23:18.000Z", "upload_time": null, "received_time": "2017-01-19", "revise_time": null, "published_info": { "page": "461-468", "issue": "3", "volume": "65" }, "article_url": null, "file_size": 0.39, "full_text": null, "article_creator": "未知", "pubmed_revise": "2018-11-13", "article_pmcid": "PMC5849051", "has_abstract": 1, "article_name": "Genomic Characterization of USA300 Methicillin-Resistant Staphylococcus aureus (MRSA) to Evaluate Intraclass", "published_time_precision": "D", "accepted_time": "2017-04-10", "journal_info": { "journal_code": "J000277", "journal_name": "Clinical Infectious Diseases" }, "is_del": 0, "original_file": "/static/file/original-article/2017/abs201808250122272103675830853018.pdf", "author_info": [ { "author_name": "Eugene V. Millar", "author_id": "au20210423171440352603438440" }, { "author_name": "Gregory K. Rice", "author_id": "au20210423120213327600460046" }, { "author_name": "Emad M. Elassal", "author_id": "au20210424175257446108716229" }, { "author_name": "Carey D. Schlett", "author_id": "au20210424151748251835746729" }, { "author_name": "Jason W. Bennett", "author_id": "au20210423202011703466314310" }, { "author_name": "Cassie L. Redden", "author_id": "au20210424211034875397991783" }, { "author_name": "Deepika Mor", "author_id": "au20210424184601751228220771" }, { "author_name": "Natasha N. Law", "author_id": "au20210424224153508353269649" }, { "author_name": "David R. Tribble", "author_id": "au20210423180440845925607301" }, { "author_name": "Theron Hamilton", "author_id": "au20210423120213911501606203" }, { "author_name": "Michael W. Ellis", "author_id": "au20210424141901970086722836" }, { "author_name": "Kimberly A. Bishop-Lilly", "author_id": "au20210423120214311393200522" } ], "abstract_section": [ { "chs_text": "美国300耐甲氧西林金黄色葡萄球菌（MRSA）的基因组特征评估高风险军事学员的内部传播和皮肤和软组织感染复发（SSTI）", "section_attr": 1, "eng_text": "Genomic Characterization of USA300 Methicillin-Resistant Staphylococcus aureus (MRSA) to Evaluate Intraclass Transmission and Recurrence of Skin and Soft Tissue Infection (SSTI) Among High-Risk Military Trainees" }, { "chs_text": "背景", "section_attr": 1, "eng_text": "Background" }, { "chs_text": "军事受训人员患甲氧西林金黄色葡萄球菌（MRSA）皮肤和软组织感染（SSTI）的风险增加。全基因组测序（WGS）可以提高我们对聚集环境中MRSA传递和微进化的理解。", "section_attr": 2, "eng_text": "Military trainees are at increased risk for methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infection (SSTI). Whole genome sequencing (WGS) can refine our understanding of MRSA transmission and microevolution in congregate settings." }, { "chs_text": "方法", "section_attr": 1, "eng_text": "Methods" }, { "chs_text": "我们在2012年7月至2014年12月期间在佐治亚州本宁堡的美国陆军步兵学员中进行了SSTI前瞻性病例对照研究。我们在选定的训练班中确定了USA300 MRSA SSTI群，并对临床分离株进行了WGS。然后，我们将基因组学，系统发育学，流行病学和临床数据联系起来，以评估细胞内和细胞间的疾病传播。此外，在复发性MRSA SSTI的病例中，我们评估了感染菌株的宿主内相关性。", "section_attr": 2, "eng_text": "We conducted a prospective case-control study of SSTI among US Army infantry trainees at Fort Benning, Georgia, from July 2012 to December 2014. We identified clusters of USA300 MRSA SSTI within select training classes and performed WGS on clinical isolates. We then linked genomic, phylogenetic, epidemiologic, and clinical data in order to evaluate intra- and interclass disease transmission. Furthermore, among cases of recurrent MRSA SSTI, we evaluated the intrahost relatedness of infecting strains." }, { "chs_text": "结果", "section_attr": 1, "eng_text": "Results" }, { "chs_text": "选择了≥5例USA300 MRSA SSTI的9个训练班。来自74名受训者的80名USA300 MRSA临床分离株，其中6名（8.1％）患有复发性感染，接受WGS治疗。我们鉴定了2719个单核苷酸变体（SNV）。分离株之间的总体中位数（范围）SNV差异为173（1-339）。组内中位数SNV差异范围为23至245.两个系统发育簇提示跨类MRSA传播。这些集群中的一个源于2个阶段，这些阶段分开了13个月但被安置在同一个营房中。在复发MRSA SSTI的受训者中，宿主中位数SNV差异为7.5（1-48）。", "section_attr": 2, "eng_text": "Nine training classes with ≥5 cases of USA300 MRSA SSTI were selected. Eighty USA300 MRSA clinical isolates from 74 trainees, 6 (8.1%) of whom had recurrent infection, were subjected to WGS. We identified 2719 single nucleotide variants (SNVs). The overall median (range) SNV difference between isolates was 173 (1-339). Intraclass median SNV differences ranged from 23 to 245. Two phylogenetic clusters were suggestive of interclass MRSA transmission. One of these clusters stemmed from 2 classes that were separated by a 13-month period but housed in the same barracks. Among trainees with recurrent MRSA SSTI, the intrahost median SNV difference was 7.5 (1-48)." }, { "chs_text": "结论", "section_attr": 1, "eng_text": "Conclusions" }, { "chs_text": "WGS的应用揭示了MRSA在军事学员中的内部和跨部门传播。 2个非同时类之间的类间群集表明在这种情况下MRSA的长期储备。", "section_attr": 2, "eng_text": "Application of WGS revealed intra- and interclass transmission of MRSA among military trainees. An interclass cluster between 2 noncontemporaneous classes suggests a long-term reservoir for MRSA in this setting." } ], "type_info": [ { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": [ "USA300", "US" ], "highlight_chs_text": [ "USA300" ] }, { "last_revised": null, "article_doi": "10.2105/AJPH.88.5.749", "has_translated": 0, "article_id": "abs20190202145004402185719950", "published_time": "1998-05", "microsoft_id": null, "article_pmid": "9585739", "article_year": "1998", "article_language": "eng", "create_time": "2019-02-02T06:50:42.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "749-54", "issue": "5", "volume": "88" }, "article_url": null, "file_size": 1.46, "full_text": null, "article_creator": "未知", "pubmed_revise": "2019-05-14", "article_pmcid": "PMC1508929", "has_abstract": 1, "article_name": "sexual behavior, public opinion, and public health policy related to sexually transmitted diseases: a US-British", "published_time_precision": "M", "accepted_time": null, "journal_info": { "journal_code": "J000955", "journal_name": "American Journal of Public Health" }, "is_del": 0, "original_file": "/static/file/original-article/1998/abs201902021450044021857199506694.pdf", "author_info": [ { "author_name": "R. T. Michael", "author_id": "au20210424124141747704176760" }, { "author_name": "J. Feinleib", "author_id": "au20210424133944372723120555" } ], "abstract_section": [ { "chs_text": null, "section_attr": 1, "eng_text": "Private sexual behavior, public opinion, and public health policy related to sexually transmitted diseases: a US-British comparison" }, { "chs_text": null, "section_attr": 1, "eng_text": "OBJECTIVES" }, { "chs_text": null, "section_attr": 2, "eng_text": "The purpose of this study was to characterize sexual behavior and opinions about sex in the United States and Britain; implications are discussed for effective public health policy regarding sexually transmitted diseases (STDs) in the United States." }, { "chs_text": null, "section_attr": 1, "eng_text": "METHODS" }, { "chs_text": null, "section_attr": 2, "eng_text": "Large-scale national probability surveys conducted in the 2 countries detailed sexual behavior, opinions, and the prevalence of STDs." }, { "chs_text": null, "section_attr": 1, "eng_text": "RESULTS" }, { "chs_text": null, "section_attr": 2, "eng_text": "In comparison with that of Britain, the US population has greater variability in sexual behavior, less tolerant opinions about sexual behavior, and a higher STD prevalence and lower condom usage among men." }, { "chs_text": null, "section_attr": 1, "eng_text": "CONCLUSIONS" }, { "chs_text": null, "section_attr": 2, "eng_text": "The survey data show compelling evidence from both countries of a strong association between number of sex partners and STD risk. In the United States relative to Britain, there is both greater dispersion in sexual behavior and a greater incidence of unconditional opposition to certain sexual practices. The former implies a need for strong public health policy to address the risks of STDs, but the latter implies strong opposition to that policy. This disjuncture between public health need and feasibility may contribute to the high US rate of STDs." } ], "type_info": [ { "type_name": "Comparative Study", "type_id": 18 }, { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": [ "US-British", "US", "usage" ] }, { "last_revised": null, "article_doi": "10.2105/AJPH.2012.300672", "has_translated": 0, "article_id": "abs20190202060606682015514172", "published_time": "2012-11", "microsoft_id": null, "article_pmid": "22994194", "article_year": "2012", "article_language": "eng", "create_time": "2019-02-01T22:07:04.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "2129-34", "issue": "11", "volume": "102" }, "article_url": null, "file_size": 0.5, "full_text": null, "article_creator": "未知", "pubmed_revise": "2018-11-13", "article_pmcid": "PMC3477934", "has_abstract": 1, "article_name": "AIDS surveillance data for New York City West Indian-born Blacks: comparisons with other immigrant and US-born", "published_time_precision": "M", "accepted_time": null, "journal_info": { "journal_code": "J000955", "journal_name": "American Journal of Public Health" }, "is_del": 0, "original_file": "/static/file/original-article/2012/abs201902020606066820155141726082.pdf", "author_info": [ { "author_name": "Susie Hoffman", "author_id": "au20210423193817343427468163" }, { "author_name": "Arpi Terzian", "author_id": "au20210424204832916036975370" } ], "abstract_section": [ { "chs_text": null, "section_attr": 1, "eng_text": "HIV/AIDS surveillance data for New York City West Indian-born Blacks: comparisons with other immigrant and US-born groups" }, { "chs_text": null, "section_attr": 1, "eng_text": "OBJECTIVES" }, { "chs_text": null, "section_attr": 2, "eng_text": "Although the risk of HIV among New York City West Indian-born Black immigrants often is assumed to be high, population-based data are lacking, a gap we aimed to address." }, { "chs_text": null, "section_attr": 1, "eng_text": "METHODS" }, { "chs_text": null, "section_attr": 2, "eng_text": "Using 2006-2007 HIV/AIDS surveillance data from the New York City Department of Health and Mental Hygiene and population data from the US Census American Community Survey 2007, we compared the rate of newly reported HIV diagnoses, prevalence of people living with HIV/AIDS, and distribution of transmission risk categories in West Indian-born Blacks, 2 other immigrant groups, and US-born Blacks and Whites." }, { "chs_text": null, "section_attr": 1, "eng_text": "RESULTS" }, { "chs_text": null, "section_attr": 2, "eng_text": "The age-adjusted rate of newly reported HIV diagnoses for West Indian-born Blacks was 43.19 per 100 000 (95% confidence interval [CI] = 38.92, 49.10). This was higher than the rate among US-born Whites (19.96; 95% CI = 18.63, 21.37) and Dominican immigrants and lower than that among US-born Blacks (109.48; 95% CI = 105.02, 114.10) and Haitian immigrants. Heterosexual transmission was the largest risk category in West Indian-born Blacks, accounting for 41% of new diagnoses." }, { "chs_text": null, "section_attr": 1, "eng_text": "CONCLUSIONS" }, { "chs_text": null, "section_attr": 2, "eng_text": "Although much lower than in US-born Blacks, the rate of newly reported HIV diagnoses in West Indian-born Blacks exceeds that among US-born Whites. Additional work is needed to understand the migration-related sources of risk." } ], "type_info": [ { "type_name": "Research Support, N.I.H., Extramural", "type_id": 60 }, { "type_name": "Comparative Study", "type_id": 18 }, { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": [ "US-born", "Using" ] }, { "last_revised": null, "article_doi": "10.1126/science.297.5584.1122a", "has_translated": 1, "article_id": "abs20181212202724320340663032", "published_time": "2002-08-16", "microsoft_id": null, "article_pmid": "12192658", "article_year": "2002", "article_language": "eng", "create_time": "2018-12-12T12:28:10.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "1122", "issue": "5584", "volume": "297" }, "article_url": null, "file_size": 0.08, "full_text": null, "article_creator": "未知", "pubmed_revise": "2019-06-19", "article_pmcid": null, "has_abstract": 1, "article_name": "A soldier's view of the USAMRIID", "published_time_precision": "D", "accepted_time": null, "journal_info": { "journal_code": "J000102", "journal_name": "Science" }, "is_del": 0, "original_file": "/static/file/original-article/2002/abs201812122027243203406630322331.pdf", "abstract_section": [ { "chs_text": "士兵对USAMRIID的看法", "section_attr": 1, "eng_text": "A soldier's view of the USAMRIID" } ], "type_info": [ { "type_name": "Letter", "type_id": 43 }, { "type_name": "Comment", "type_id": 17 } ], "highlight_eng_text": [ "USAMRIID" ], "highlight_chs_text": [ "USAMRIID" ] }, { "last_revised": null, "article_doi": "10.1038/s41467-019-12641-4", "has_translated": 0, "article_id": "abs20191207212024779645523565", "published_time": "2019-10-11", "microsoft_id": null, "article_pmid": "31604943", "article_year": "2019", "article_language": "eng", "create_time": "2019-12-07T13:20:24.000Z", "upload_time": null, "received_time": "2018-11-21", "revise_time": null, "published_info": { "page": "4670", "issue": "1", "volume": "10" }, "article_url": null, "file_size": 6.02, "full_text": null, "article_creator": "未知", "pubmed_revise": "2020-02-04", "article_pmcid": "PMC6789044", "has_abstract": 1, "article_name": "HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling", "published_time_precision": "D", "accepted_time": "2019-09-21", "journal_info": { "journal_code": "J000075", "journal_name": "Nature Communications" }, "is_del": 0, "original_file": "/static/file/original-article/2019/abs201912072120247796455235655197.pdf", "author_info": [ { "author_name": "Areum Park", "author_id": "au20210424165609148928591487" }, { "author_name": "Eun A. Ra", "author_id": "au20210424165609160939824276" }, { "author_name": "Taeyun A. Lee", "author_id": "au20210424165609168946856800" }, { "author_name": "Hyun Jin Choi", "author_id": "au20210423150029076337871261" }, { "author_name": "Eunhye Lee", "author_id": "au20210423115812199224866940" }, { "author_name": "Sujin Kang", "author_id": "au20210423125720930627516807" }, { "author_name": "Jun-Young Seo", "author_id": "au20210424140347411028550163" }, { "author_name": "Sungwook Lee", "author_id": "au20210424140405646668373094" }, { "author_name": "Boyoun Park", "author_id": "au20210424140405652673853919" } ], "abstract_section": [ { "chs_text": null, "section_attr": 1, "eng_text": "HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways" }, { "chs_text": null, "section_attr": 2, "eng_text": "The mechanisms by which many human cytomegalovirus (HCMV)-encoded proteins help the virus to evade immune surveillance remain poorly understood. In particular, it is unknown whether HCMV proteins arrest Toll-like receptor (TLR) signaling pathways required for antiviral defense. Here, we report that US7 and US8 as key suppressors that bind both TLR3 and TLR4, facilitating their destabilization by distinct mechanisms. US7 exploits the ER-associated degradation components Derlin-1 and Sec61, promoting ubiquitination of TLR3 and TLR4. US8 not only disrupts the TLR3-UNC93B1 association but also targets TLR4 to the lysosome, resulting in rapid degradation of the TLR. Accordingly, a mutant HCMV lacking the US7-US16 region has an impaired ability to hinder TLR3 and TLR4 activation, and the impairment is reversed by the introduction of US7 or US8. Our findings reveal an inhibitory effect of HCMV on TLR signaling, which contributes to persistent avoidance of the host antiviral response to achieve viral latency." } ], "type_info": [ { "type_name": "Research Support, Non-U.S. Gov't", "type_id": 62 }, { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": { "0": "US7", "1": "US8", "5": "US7-US", "7": "US8." } }, { "last_revised": null, "article_doi": "10.1097/QAI.0b013e31811ed1dc", "has_translated": 0, "article_id": "abs20190202034706799833224650", "published_time": "2007-08-15", "microsoft_id": null, "article_pmid": "17589372", "article_year": "2007", "article_language": "eng", "create_time": "2019-02-01T19:48:04.000Z", "upload_time": null, "received_time": null, "revise_time": null, "published_info": { "page": "529-34", "issue": "5", "volume": "45" }, "article_url": null, "file_size": 0.08, "full_text": null, "article_creator": "未知", "pubmed_revise": "2007-12-03", "article_pmcid": null, "has_abstract": 1, "article_name": "Differences in HIV-related hospitalization trends between Haitian-born blacks and US-born blacks", "published_time_precision": "D", "accepted_time": null, "journal_info": { "journal_code": "J000921", "journal_name": "Journal of Acquired Immune Deficiency Syndromes" }, "is_del": 0, "original_file": "/static/file/original-article/2007/abs201902020347067998332246507617.pdf", "author_info": [ { "author_name": "Allan E. Rodriguez", "author_id": "au20210424143642367523829876" } ], "abstract_section": [ { "chs_text": null, "section_attr": 1, "eng_text": "Differences in HIV-related hospitalization trends between Haitian-born blacks and US-born blacks" }, { "chs_text": null, "section_attr": 1, "eng_text": "OBJECTIVES" }, { "chs_text": null, "section_attr": 2, "eng_text": "To examine the HIV care needs and hospital admission patterns of HIV-positive Haitian-born blacks (Haitians) and compare them with those of US-born blacks (Blacks)." }, { "chs_text": null, "section_attr": 1, "eng_text": "METHODS" }, { "chs_text": null, "section_attr": 2, "eng_text": "We abstracted the medical records of 635 Blacks and Haitians consecutively admitted to the adult HIV Service at Jackson Memorial Hospital during 2004 for information on demographics, use of antiretroviral therapy, CD4 cell counts, primary and secondary diagnoses at admission, and substance use. The probability of being prescribed highly active antiretroviral therapy (HAART) was examined by country of origin." }, { "chs_text": null, "section_attr": 1, "eng_text": "RESULTS" }, { "chs_text": null, "section_attr": 2, "eng_text": "There was no statistically significant difference between the groups in likelihood to be prescribed HAART. In controlled analyses, however, Haitians were 76% more likely than Blacks to have a CD4 count <51 cells/mm3 and tended to be more recently diagnosed with HIV Moreover, tuberculosis was the most prevalent opportunistic infection for Haitians compared with candidiasis for Blacks." }, { "chs_text": null, "section_attr": 1, "eng_text": "CONCLUSIONS" }, { "chs_text": null, "section_attr": 2, "eng_text": "Findings suggest that barriers to medical care may exist for Haitians at an early stage of the access continuum and that prevention efforts among the Haitian HIV-positive population should be directed at promoting the need for timely use of health services." } ], "type_info": [ { "type_name": "Research Support, U.S. Gov't, P.H.S.", "type_id": 64 }, { "type_name": "Comparative Study", "type_id": 18 }, { "type_name": "Journal Article", "type_id": 39 } ], "highlight_eng_text": { "0": "US-born", "2": "use" } } ], "count": 9641, "page_now": 1, "page_num": 20 }

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